AbSolution
Explore immune receptor repertoires through sequence-derived features - reproducibly and at scale
Rodrigo García-Valiente et al
Key results
577 features associated with T-cell viral antigen-driven expansion
368 features distinguishing dominant B-cell clones in myositis
Explore clonal populations (shared vs unique, dominant vs non-dominant, over-expanded vs under-expanded)
Reproducibility by design: winner of the Amsterdam UMC Open Science Award 2025
Summary
AbSolution is an interactive R-based application for the exploration and analysis of adaptive immune receptor repertoires (BCR and TCR). It enables integrated investigation of sequence-derived features, including physicochemical, compositional, and mutation-related properties across receptor regions and biological groupings.We demonstrate its utility in identifying differences between dominant and non-dominant B-cell myositis clonotypes, as well as antigen-responsive T-cell populations across time. AbSolution is designed with reproducibility at its core, integrating the ENCORE framework to ensure transparent and fully reproducible workflows. The reproducibility of the application has been independently validated by the CODECHECK initiative.Feel free to reach out!!
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